Xiamen Talent Biomedical Technology Co.,Ltd.

Fujian,China

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Fujian,China

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Fujian,China

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MLH1 Antibody (Immunohistochemistry)

FOB Price : Get a Price/Quote

Min.Order : 1 Piece(s)

Certification : CFDA,CE

Brand Name : Talent Biomedical

Payment Terms : T/T

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product information

brand name : Talent Biomedical
certification : CFDA,CE
min.order : 1 Piece(s)
warranty : 18 Months
payment terms : T/T
Packaging : 0.2ml, 1ml, 3ml, 6ml, 11ml
Specification : /
place of origin : China

product description

MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumours that are microsatellite-unstable. Add the primary antibody to bind the antigen on tissue sections, and then use HRP labeled secondary antibody binding primary antibody to form the secondary antibody-primary antibody-antigen complex. When DAB chromogenic solution is added, HRP reacts with enzyme substrate to produce brown insoluble reaction product, which indirectly indicating the existence of antigen.